![]() We therefore aim to perform a randomised control trial, comparing 0.03% indigo-carmine dye versus 0.2% in detecting dysplasia in patients undergoing surveillance colonoscopy in IBD. However there are no trials comparing the two methods and no previous trials have used the 0.03%. The recent international SCENIC guidelines suggest using 0.03% indigo-carmine via a foot pump. We have recently shown that 0.2% dye improves detection rates compared to high definition white light. Studies have used different concentrations of indigo-carmine dye ranging from 0.1 to 0.4%. There is no standard international concentration of the dye spray used during chromoendoscopy. Until recently, IBD surveillance has relied upon colonoscopy with multiple (at least 33) random biopsies of the bowel lining to detect dysplasia, but now international guidelines recommended a technique called chromoendoscopy.Ĭhromoendoscopy involves applying a dye, called indigo-carmine, to the bowel lining whilst performing colonoscopy which highlights more subtle abnormalities, therefore increasing dysplasia detection rate. This is thought to detect early mucosal (interior bowel lining) abnormalities, known as dysplasia, which can progress to CRC. Therefore patients with longstanding colitis undergo regular screening colonoscopy at varied time intervals depending on their individual risk. ![]() Patients with longstanding ulcerative colitis (inflammatory bowel disease, IBD) have increased risk of developing colorectal cancer (CRC) when compared with that of the general population.
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